General Information:

Id: 3,503 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
PPARalpha-/- mouse
article
Reference: Makowski L et al.(2009) Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation FASEB J. 23: 586-604 [PMID: 18945875]

Interaction Information:

Comment On the basis of the pronounced C5 peak the study evaluated skeletal muscle expression of isovaleryl-CoA dehydrogenase (IVD) and HMG-CoA lyase (HMGCL), mitochondrial enzymes required for leucine catabolism to acetyl-CoA. Consistent with the metabolite profiles, a starvation-induced increase in IVD expression was observed in the PPARalpha null mice but not in the wild-type controls. HMGCL was unaffected by genotype.
Formal Description
Interaction-ID: 32617

gene/protein

PPARA

affects_expression of

gene/protein

IVD

in skeletal muscle
Drugbank entries Show/Hide entries for PPARA or IVD