General Information:

Id: 3,503 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
PPARalpha-/- mouse
article
Reference: Makowski L et al.(2009) Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation FASEB J. 23: 586-604 [PMID: 18945875]

Interaction Information:

Comment Loss of PPARalpha resulted in reduced muscle levels of most organic acids. This was evident in the fed state and exacerbated by fasting, which caused a further drop in alpha-ketoglutarate, succinate, and fumarate, along with marginal declines in citrate and malate.
Formal Description
Interaction-ID: 32597

gene/protein

PPARA

affects_quantity of

drug/chemical compound

Fumarate

in skeletal muscle
Drugbank entries Show/Hide entries for PPARA or Fumarate