General Information:

Id: 3,503 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
PPARalpha-/- mouse
article
Reference: Makowski L et al.(2009) Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation FASEB J. 23: 586-604 [PMID: 18945875]

Interaction Information:

Comment In the absence of PPARalpha, hepatic citrate levels decreased, whereas fumarate and malate increased; these changes were detected as a main effect of genotype.
Formal Description
Interaction-ID: 32583

gene/protein

PPARA

affects_quantity of

drug/chemical compound

Malate

in liver
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