General Information:

Id: 3,503 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
PPARalpha-/- mouse
article
Reference: Makowski L et al.(2009) Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation FASEB J. 23: 586-604 [PMID: 18945875]

Interaction Information:

Comment Gene expression of gammabutyrobetaine hydroxylase 1 (Bbox1), a liver-specific enzyme that catalyzes the final and rate-limiting step in carnitine synthesis, was induced 30% on fasting in PPARalpha +/+ mice but suppressed 65% in PPARalpha -/- mice.
Formal Description
Interaction-ID: 32569

gene/protein

PPARA

affects_expression of

gene/protein

BBOX1

in liver
Drugbank entries Show/Hide entries for PPARA or BBOX1