General Information:

Id: 35
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0002181 HEK-293T cell
article
Reference: Yang X et al.(1997) Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89: 1067-1076 [PMID: 9215629]

Interaction Information:

Comment The signaling protein Daxx binds specifically to the Fas death domain.
Formal Description
Interaction-ID: 83

gene/protein

DAXX

interacts (colocalizes) with

gene/protein

FAS

Drugbank entries Show/Hide entries for FAS
Comment In 293 cells, transient overexpression of Fas induced apoptosis in a dose-dependent and saturable manner.
Formal Description
Interaction-ID: 84

gene/protein

FAS

increases_activity of

Drugbank entries Show/Hide entries for FAS
Comment Coexpression of DAXX and FAS enhances Fas-mediated apoptosis.
Formal Description
Interaction-ID: 85

gene/protein

DAXX

increases_activity of

Comment Daxx activates the JNK pathway, which is required in certain cell lines for the analogous TNF-alpha-induced apoptosis.
Formal Description
Interaction-ID: 86

gene/protein

DAXX

increases_activity of