General Information:

Id: 3,495 (click here to show other Interactions for entry)
Diseases: Hepatocellular carcinoma - [OMIM]
Homo sapiens
BTO:0000599 Hep-G2 cell
article
Reference: Mottet D et al.(2003) Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells J. Biol. Chem. 278 [PMID: 12764143]

Interaction Information:

Comment Although the PI3K/Akt1 activity is diminished after 5-h incubation in hypoxia, the residual activity of this pathway is sufficient and necessary to sustain HIF-1alpha accumulation.
Formal Description
Interaction-ID: 32454

decreases_activity of

gene/protein

AKT1

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