Mottet D et al.(2003) Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells J. Biol. Chem. 278
[PMID: 12764143]
Interaction Information:
Comment
Although the PI3K/Akt1 activity is diminished after 5-h incubation in hypoxia, the residual activity of this pathway is sufficient and necessary to sustain HIF-1alpha accumulation.
Although the PI3K/Akt1 activity is diminished after 5-h incubation in hypoxia, the residual activity of this pathway is sufficient and necessary to sustain HIF-1alpha accumulation.
CIDeR