General Information:

Id: 3,471 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Bain JR et al.(2009) Metabolomics applied to diabetes research: moving from information to knowledge Diabetes 58: 2429-2443 [PMID: 19875619]

Interaction Information:

Comment Nuclear receptors, including the family of PPAR-alpha, -delta, and -gamma, have emerged as important mediators of insulin sensitivity. 1H-NMR-, LC-MS-, and GC-MS-based methods were used to compare PPAR-alpha null and wild-type mice. The authors reported decreases in glucose, glutamine, and alanine levels and an increase in lactate, suggesting an increase in utilization of glucose and amino acids, as might be predicted from the known effects of PPAR-alpha to promote the opposing pathways of beta-oxidation, ketogenesis, and gluconeogenesis.
Formal Description
Interaction-ID: 32365

gene/protein

PPARA

affects_quantity of

drug/chemical compound

Glucose

Drugbank entries Show/Hide entries for PPARA
Comment Nuclear receptors, including the family of PPAR-alpha, -delta, and -gamma, have emerged as important mediators of insulin sensitivity. 1H-NMR-, LC-MS-, and GC-MS-based methods were used to compare PPAR-alpha null and wild-type mice. The authors reported decreases in glucose, glutamine, and alanine levels and an increase in lactate, suggesting an increase in utilization of glucose and amino acids, as might be predicted from the known effects of PPAR-alpha to promote the opposing pathways of beta-oxidation, ketogenesis, and gluconeogenesis.
Formal Description
Interaction-ID: 32378

gene/protein

PPARA

affects_quantity of

drug/chemical compound

Glutamine

Drugbank entries Show/Hide entries for PPARA
Comment Nuclear receptors, including the family of PPAR-alpha, -delta, and -gamma, have emerged as important mediators of insulin sensitivity. 1H-NMR-, LC-MS-, and GC-MS-based methods were used to compare PPAR-alpha null and wild-type mice. The authors reported decreases in glucose, glutamine, and alanine levels and an increase in lactate, suggesting an increase in utilization of glucose and amino acids, as might be predicted from the known effects of PPAR-alpha to promote the opposing pathways of beta-oxidation, ketogenesis, and gluconeogenesis.
Formal Description
Interaction-ID: 32382

gene/protein

PPARA

affects_quantity of

drug/chemical compound

Alanine

Drugbank entries Show/Hide entries for PPARA
Comment Nuclear receptors, including the family of PPAR-alpha, -delta, and -gamma, have emerged as important mediators of insulin sensitivity. 1H-NMR-, LC-MS-, and GC-MS-based methods were used to compare PPAR-alpha null and wild-type mice. The authors reported decreases in glucose, glutamine, and alanine levels and an increase in lactate, suggesting an increase in utilization of glucose and amino acids, as might be predicted from the known effects of PPAR-alpha to promote the opposing pathways of beta-oxidation, ketogenesis, and gluconeogenesis.
Formal Description
Interaction-ID: 32385

gene/protein

PPARA

affects_quantity of

drug/chemical compound

Lactate

Drugbank entries Show/Hide entries for PPARA
Comment Nuclear receptors, including the family of PPAR-alpha, -delta, and -gamma, have emerged as important mediators of insulin sensitivity. 1H-NMR-, LC-MS-, and GC-MS-based methods were used to compare PPAR-alpha null and wild-type mice. The authors reported decreases in glucose, glutamine, and alanine levels and an increase in lactate, suggesting an increase in utilization of glucose and amino acids, as might be predicted from the known effects of PPAR-alpha to promote the opposing pathways of beta-oxidation, ketogenesis, and gluconeogenesis.
Formal Description
Interaction-ID: 32387

gene/protein

PPARA

affects_activity of

Drugbank entries Show/Hide entries for PPARA
Comment Nuclear receptors, including the family of PPAR-alpha, -delta, and -gamma, have emerged as important mediators of insulin sensitivity. 1H-NMR-, LC-MS-, and GC-MS-based methods were used to compare PPAR-alpha null and wild-type mice. The authors reported decreases in glucose, glutamine, and alanine levels and an increase in lactate, suggesting an increase in utilization of glucose and amino acids, as might be predicted from the known effects of PPAR-alpha to promote the opposing pathways of beta-oxidation, ketogenesis, and gluconeogenesis.
Formal Description
Interaction-ID: 32388

gene/protein

PPARA

affects_activity of

Drugbank entries Show/Hide entries for PPARA
Comment Nuclear receptors, including the family of PPAR-alpha, -delta, and -gamma, have emerged as important mediators of insulin sensitivity. 1H-NMR-, LC-MS-, and GC-MS-based methods were used to compare PPAR-alpha null and wild-type mice. The authors reported decreases in glucose, glutamine, and alanine levels and an increase in lactate, suggesting an increase in utilization of glucose and amino acids, as might be predicted from the known effects of PPAR-alpha to promote the opposing pathways of beta-oxidation, ketogenesis, and gluconeogenesis.
Formal Description
Interaction-ID: 32390

gene/protein

PPARA

affects_activity of

process

gluconeogenesis

Drugbank entries Show/Hide entries for PPARA
Comment Targeted GC-MS and LC-MS-MS analysis has provided deeper insights by showing that PPAR-alpha knockout results in fasting hypoglycemia accompanied by depletion of TCA cycle intermediates and free carnitine and short-chain acylcarnitines, as well as accumulation of long-chain acyl CoAs in skeletal muscle.
Formal Description
Interaction-ID: 32391

gene/protein

PPARA

affects_activity of

phenotype

hypoglycemia

after fasting
Drugbank entries Show/Hide entries for PPARA
Comment Targeted GC-MS and LC-MS-MS analysis has provided deeper insights by showing that PPAR-alpha knockout results in fasting hypoglycemia accompanied by depletion of TCA cycle intermediates and free carnitine and short-chain acylcarnitines, as well as accumulation of long-chain acyl CoAs in skeletal muscle.
Formal Description
Interaction-ID: 32393

gene/protein

PPARA

affects_activity of

Drugbank entries Show/Hide entries for PPARA
Comment Targeted GC-MS and LC-MS-MS analysis has provided deeper insights by showing that PPAR-alpha knockout results in fasting hypoglycemia accompanied by depletion of TCA cycle intermediates and free carnitine and short-chain acylcarnitines, as well as accumulation of long-chain acyl CoAs in skeletal muscle.
Formal Description
Interaction-ID: 32394

gene/protein

PPARA

affects_quantity of

drug/chemical compound

Carnitine

Drugbank entries Show/Hide entries for PPARA
Comment Targeted GC-MS and LC-MS-MS analysis has provided deeper insights by showing that PPAR-alpha knockout results in fasting hypoglycemia accompanied by depletion of TCA cycle intermediates and free carnitine and short-chain acylcarnitines, as well as accumulation of long-chain acyl CoAs in skeletal muscle.
Formal Description
Interaction-ID: 32397

gene/protein

PPARA

affects_quantity of

drug/chemical compound

Short-chain acylcarnitine

Drugbank entries Show/Hide entries for PPARA
Comment Targeted GC-MS and LC-MS-MS analysis has provided deeper insights by showing that PPAR-alpha knockout results in fasting hypoglycemia accompanied by depletion of TCA cycle intermediates and free carnitine and short-chain acylcarnitines, as well as accumulation of long-chain acyl CoAs in skeletal muscle.
Formal Description
Interaction-ID: 32400

gene/protein

PPARA

affects_quantity of

drug/chemical compound

Long-chain acyl-CoA

Drugbank entries Show/Hide entries for PPARA