General Information:

Id: 3,471 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Bain JR et al.(2009) Metabolomics applied to diabetes research: moving from information to knowledge Diabetes 58: 2429-2443 [PMID: 19875619]

Interaction Information:

Comment Nuclear receptors, including the family of PPAR-alpha, -delta, and -gamma, have emerged as important mediators of insulin sensitivity. 1H-NMR-, LC-MS-, and GC-MS-based methods were used to compare PPAR-alpha null and wild-type mice. The authors reported decreases in glucose, glutamine, and alanine levels and an increase in lactate, suggesting an increase in utilization of glucose and amino acids, as might be predicted from the known effects of PPAR-alpha to promote the opposing pathways of beta-oxidation, ketogenesis, and gluconeogenesis.
Formal Description
Interaction-ID: 32385

gene/protein

PPARA

affects_quantity of

drug/chemical compound

Lactate

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