General Information:

Id: 3,471 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Reference: Bain JR et al.(2009) Metabolomics applied to diabetes research: moving from information to knowledge Diabetes 58: 2429-2443 [PMID: 19875619]

Interaction Information:

Comment Application of NMR and MS-based tools led to the discovery of a critical link between pyruvate carboxylase (PC)-mediated pyruvate exchange with tricarboxylic acid (TCA) cycle intermediates (pyruvate cycling) and glucose-stimulated insulin secretion (GSIS) and demonstration that these pathways are dysregulated in lipid-cultured and dysfunctional beta-cells. One important pathway appears to involve export of citrate and/or isocitrate from the mitochondria via the citrate/isocitrate carrier (CIC) and subsequent conversion of isocitrate to alpha-ketoglutarate (alpha-KG) by the cytosolic NAPD-dependent isoform of isocitrate dehydrogenase (ICDc).
Formal Description
Interaction-ID: 32314