General Information:

Id: 344 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
article
Reference: Takasugi N et al.(2003) The role of presenilin cofactors in the gamma-secretase complex. Nature 422: 438-441 [PMID: 12660785]

Interaction Information:

Comment APH-1 stabilizes the presenilin holoprotein in the complex, whereas PEN-2 is required for endoproteolytic processing of presenilin and conferring gamma-secretase activity to the complex.
Formal Description
Interaction-ID: 1345

gene/protein

PSENEN

affects_activity of

gene/protein

PSEN1

Comment APH-1 stabilizes the presenilin holoprotein in the complex, whereas PEN-2 is required for endoproteolytic processing of presenilin and conferring gamma-secretase activity to the complex.
Formal Description
Interaction-ID: 1350

gene/protein

APH1A

increases_activity of

gene/protein

PSEN1

APH-1 stabilizes the presenilin holoprotein.
Comment APH-1 stabilizes the presenilin holoprotein in the complex, whereas PEN-2 is required for endoproteolytic processing of presenilin and conferring gamma-secretase activity to the complex.
Formal Description
Interaction-ID: 25279

gene/protein

PSENEN

affects_processing of

gene/protein

PSEN1