General Information:

Id: 3,445 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Sus scrofa
Reference: Keller J et al.(2011) Effect of L-carnitine on the hepatic transcript profile in piglets as animal model Nutr Metab (Lond) 8: 76 [PMID: 22040461]

Interaction Information:

Comment Clustering analysis further revealed that L-carnitine supplementation was significantly associated with biological processes involved in glucose metabolism, like glucose transport, conversion of glucose into glucose 6-phosphate, and glycolysis, and hexose biosynthetic processes, like gluconeogenesis. Representative genes included GLUT8 (glucose transporter type 8), GCK (Hexokinase D), GPD1 (Glycerol-3-phosphate dehydrogenase), PCK1 (Phosphoenolpyruvate carboxykinase), and FBP2 (Fructose1,6-bisphosphatase isozyme 2). Moreover, the tandem enzyme PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3) which is responsible for maintaining the cellular levels of fructose-2,6-biphosphate, the most potent allosteric activator of one of the key regulatory enzymes of glycolysis, 6-phosphofructo-1-kinase, was also identified to be differentially expressed by L-carnitine. All the genes dealing with glucose metabolism like GLUT8, GCK and GPD1 were markedly up-regulated, at least 4-fold, by the supplemental L-carnitine. GCK which is the predominant hexokinase isoenzyme in the liver phosphorylating glucose for subsequent metabolism by either glycolysis, pentose phosphate shunt or glycogen synthesis was even induced 27-fold by L-carnitine supplementation - indicating that L-carnitine has a dramatic effect on glucose metabolism.
Formal Description
Interaction-ID: 32183


carnitine supplementation

affects_activity of