General Information:

Id: 341
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
ob/ob mouse
article
Reference: Lin HZ et al.(2000) Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat. Med. 6: 998-1003 [PMID: 10973319]

Interaction Information:

Comment Metformin improved fatty liver disease, reversing hepatomegaly, steatosis and aminotransferase abnormalities.
Formal Description
Interaction-ID: 1339

drug/chemical compound

Metformin

decreases_activity of

disease

Fatty liver disease, nonalcoholic

in ob/ob mice
Drugbank entries Show/Hide entries for Metformin
Comment Metformin treatment decreases the DNA-binding activity or SREBP-1 in mouse liver nuclear extracts.
Formal Description
Interaction-ID: 1343

drug/chemical compound

Metformin

decreases_activity of

gene/protein

SREBF1

in liver
Drugbank entries Show/Hide entries for Metformin
Comment Metformin-related decreases in hepatic TNF-alpha mRNA concentrations are associated with a significant down-regulation of UCP-2 mRNA concentrations in liver.
Formal Description
Interaction-ID: 1344

drug/chemical compound

Metformin

decreases_expression of

gene/protein

TNF

in liver
Drugbank entries Show/Hide entries for Metformin or TNF
Comment Metformin-related decreases in hepatic TNF-alpha mRNA concentrations are associated with a significant down-regulation of UCP-2 mRNA concentrations in liver.
Formal Description
Interaction-ID: 1348

drug/chemical compound

Metformin

decreases_expression of

gene/protein

UCP2

in liver
Drugbank entries Show/Hide entries for Metformin
Comment Metformin-treatment reduced hepatocyte FAS expression.
Formal Description
Interaction-ID: 1356

drug/chemical compound

Metformin

decreases_expression of

gene/protein

FASN

in liver
Drugbank entries Show/Hide entries for Metformin or FASN