General Information:

Id: 340 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0002181 HEK-293T cell
article
Reference: Ho CC et al.(2009) The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration. J. Neurosci. 29: 1011-1016 [PMID: 19176810]

Interaction Information:

Comment Expression of exogenous FADD significantly increased the amount of caspase-8 that co-purified with LRRK2, suggesting that LRRK2, FADD, and caspase-8 are components of a multiprotein complex.
Formal Description
Interaction-ID: 1385

increases_activity of

process

neuron death