General Information:

Id: 3,387 (click here to show other Interactions for entry)
Diseases: Carnitine deficiency, systemic primary - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Vaz FM and Wanders RJ(2002) Carnitine biosynthesis in mammals Biochem. J. Pt: 3 417-429 [PMID: 11802770]

Interaction Information:

Comment Clofibrate, a peroxisome proliferator and ligand for the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), greatly increased liver carnitine and acylcarnitine concentrations (by 6- and 5-fold respectively). These increases were a result of enhanced hepatic carnitine biosynthesis, and not of redistribution of carnitine among tissues or of a decrease in urinary excretion.
Formal Description
Interaction-ID: 31622

drug/chemical compound

Clofibrate

increases_activity of

gene/protein

PPARA

Drugbank entries Show/Hide entries for Clofibrate or PPARA