General Information:

Id: 3,346 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
diet-induced obesity (DIO) C57BL/6 mouse
article
Reference: Veniant MM et al.(2009) Time of the day for 11beta-HSD1 inhibition plays a role in improving glucose homeostasis in DIO mice Diabetes Obes Metab 11: 109-117 [PMID: 18479468]

Interaction Information:

Comment The 11beta-HSD1 inhibitor, compound 2922, exhibited maximum efficacy if dosed in the afternoon when plasma corticosterone is high; the morning dosing when plasma corticosterone is low did not lead to efficacy.
Formal Description
Interaction-ID: 30743

affects_activity of

drug/chemical compound

Compound 2922