CIDeRGeneral Information:
| Id: | 3,346 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Obesity - [OMIM] |
| Mus musculus | |
| male | |
| diet-induced obesity (DIO) C57BL/6 mouse | |
| article | |
| Reference: | Veniant MM et al.(2009) Time of the day for 11beta-HSD1 inhibition plays a role in improving glucose homeostasis in DIO mice Diabetes Obes Metab 11: 109-117 [PMID: 18479468] |
Interaction Information:
| Comment | Corticosterone circadian rhythm was similar between lean and DIO C57BL/6 mice, and 11beta-HSD1 enzyme activity undergoes minimal variations throughout the day. |
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Formal Description Interaction-ID: 30739 |
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| Comment | Corticosterone circadian rhythm was similar between lean and DIO C57BL/6 mice, and 11beta-HSD1 enzyme activity undergoes minimal variations throughout the day. |
|
Formal Description Interaction-ID: 30740 |
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| Drugbank entries | Show/Hide entries for HSD11B1 |
| Comment | The 11beta-HSD1 inhibitor, compound 2922, exhibited maximum efficacy if dosed in the afternoon when plasma corticosterone is high; the morning dosing when plasma corticosterone is low did not lead to efficacy. |
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Formal Description Interaction-ID: 30743 |
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