General Information:

Id: 3,344
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
BTO:0000988 pancreas
article
Reference: Schmid J et al.(2011) Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11beta-hydroxysteroid dehydrogenase Proc. Natl. Acad. Sci. U.S.A. 108 [PMID: 21825133]

Interaction Information:

Comment Corticotropin-releasing hormone (CRH) and growth hormone-releasing hormone (GHRH) have been characterized as neuroregulators of the hypothalamic-pituitary-adrenal axis (HPA-axis). The study demonstrates expression of mRNA for CRH and CRH-receptor type 1 (CRHR1) and of protein for CRHR1 in rat and human pancreatic islets and rat insulinoma cells.
Formal Description
Interaction-ID: 30710

gene/protein

CRH

is_expressed_in

tissue/cell line

pancreatic islet

Drugbank entries Show/Hide entries for CRH
Comment Corticotropin-releasing hormone (CRH) and growth hormone-releasing hormone (GHRH) have been characterized as neuroregulators of the hypothalamic-pituitary-adrenal axis (HPA-axis). The study demonstrates expression of mRNA for CRH and CRH-receptor type 1 (CRHR1) and of protein for CRHR1 in rat and human pancreatic islets and rat insulinoma cells.
Formal Description
Interaction-ID: 30712

gene/protein

CRHR1

is_expressed_in

tissue/cell line

pancreatic islet

Comment Activation of CRHR1 and GHRH-receptor significantly increased cell proliferation and reduced cell apoptosis.
Formal Description
Interaction-ID: 30714

gene/protein

CRHR1

increases_activity of

Comment Activation of CRHR1 and GHRH-receptor significantly increased cell proliferation and reduced cell apoptosis.
Formal Description
Interaction-ID: 30715

gene/protein

GHRHR

increases_activity of

Drugbank entries Show/Hide entries for GHRHR
Comment Activation of CRHR1 and GHRH-receptor significantly increased cell proliferation and reduced cell apoptosis.
Formal Description
Interaction-ID: 30716

gene/protein

CRHR1

decreases_activity of

Comment Activation of CRHR1 and GHRH-receptor significantly increased cell proliferation and reduced cell apoptosis.
Formal Description
Interaction-ID: 30717

gene/protein

GHRHR

decreases_activity of

Drugbank entries Show/Hide entries for GHRHR
Comment CRH stimulated both cellular content and release of insulin in rat islet and insulinoma cells.
Formal Description
Interaction-ID: 30718

gene/protein

CRH

increases_activity of

Drugbank entries Show/Hide entries for CRH
Comment CRH stimulated both cellular content and release of insulin in rat islet and insulinoma cells.
Formal Description
Interaction-ID: 30719

gene/protein

CRH

increases_quantity of

complex/PPI

Insulin

Drugbank entries Show/Hide entries for CRH
Comment The study demonstrated expression of mRNA for 11beta-HSD-1 and 11beta-HSD-2 and protein for 11beta-HSD-1 in rat and human pancreatic islets and insulinoma cells.
Formal Description
Interaction-ID: 30720

gene/protein

HSD11B1

is_expressed_in

tissue/cell line

pancreatic islet

Drugbank entries Show/Hide entries for HSD11B1
Comment The study demonstrated expression of mRNA for 11beta-HSD-1 and 11beta-HSD-2 and protein for 11beta-HSD-1 in rat and human pancreatic islets and insulinoma cells.
Formal Description
Interaction-ID: 30721

gene/protein

HSD11B2

is_expressed_in

tissue/cell line

pancreatic islet

Drugbank entries Show/Hide entries for HSD11B2
Comment Quantitative real-time PCR revealed that stimulation of CRHR1 and GHRH-receptor affects the metabolism of insulinoma cells by down-regulating 11beta-HSD-1 and up-regulating 11beta-HSD-2.
Formal Description
Interaction-ID: 30723

gene/protein

CRH

increases_activity of

gene/protein

CRHR1

Drugbank entries Show/Hide entries for CRH
Comment Quantitative real-time PCR revealed that stimulation of CRHR1 and GHRH-receptor affects the metabolism of insulinoma cells by down-regulating 11beta-HSD-1 and up-regulating 11beta-HSD-2.
Formal Description
Interaction-ID: 30724

gene/protein

CRHR1

decreases_expression of

gene/protein

HSD11B1

Drugbank entries Show/Hide entries for HSD11B1
Comment Quantitative real-time PCR revealed that stimulation of CRHR1 and GHRH-receptor affects the metabolism of insulinoma cells by down-regulating 11beta-HSD-1 and up-regulating 11beta-HSD-2.
Formal Description
Interaction-ID: 30725

gene/protein

CRHR1

increases_expression of

gene/protein

HSD11B2

Drugbank entries Show/Hide entries for HSD11B2
Comment Quantitative real-time PCR revealed that stimulation of CRHR1 and GHRH-receptor affects the metabolism of insulinoma cells by down-regulating 11beta-HSD-1 and up-regulating 11beta-HSD-2.
Formal Description
Interaction-ID: 30726

gene/protein

GHRH

increases_activity of

gene/protein

GHRHR

Drugbank entries Show/Hide entries for GHRHR
Comment Quantitative real-time PCR revealed that stimulation of CRHR1 and GHRH-receptor affects the metabolism of insulinoma cells by down-regulating 11beta-HSD-1 and up-regulating 11beta-HSD-2.
Formal Description
Interaction-ID: 30727

gene/protein

GHRHR

decreases_expression of

gene/protein

HSD11B1

Drugbank entries Show/Hide entries for GHRHR or HSD11B1
Comment Quantitative real-time PCR revealed that stimulation of CRHR1 and GHRH-receptor affects the metabolism of insulinoma cells by down-regulating 11beta-HSD-1 and up-regulating 11beta-HSD-2.
Formal Description
Interaction-ID: 30728

gene/protein

GHRHR

increases_expression of

gene/protein

HSD11B2

Drugbank entries Show/Hide entries for GHRHR or HSD11B2
Comment Activation of CRHR1 resulted in reduced cortisol levels, indicating either decreased 11beta-HSD-1 enzyme activity or increased 11beta-HSD-2 enzyme activity; thus, activation of CRHR1 alters the glucocorticoid balance toward the inactive form.
Formal Description
Interaction-ID: 30729

gene/protein

CRHR1

increases_activity of

phenotype

decreased cortisol level