General Information:

Id: 3,340 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Homo sapiens
male
article
Reference: Andrews RC et al.(2003) Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes J. Clin. Endocrinol. Metab. 88: 285-291 [PMID: 12519867]

Interaction Information:

Comment Six diet-controlled nonobese diabetic patients with hemoglobin A(1c) less than 8%, and six matched controls participated in a double-blind, cross-over comparison of carbenoxolone (100 mg every 8 h, orally, for 7 d) and placebo. Carbenoxolone had the expected effects of raising blood pressure and lowering plasma potassium. Carbenoxolone reduced total cholesterol in healthy subjects, but had no effect on other serum lipids or on cholesterol in diabetic patients.
Formal Description
Interaction-ID: 30695

drug/chemical compound

Carbenoxolone

decreases_quantity of

drug/chemical compound

Cholesterol

in healthy lean males
Drugbank entries Show/Hide entries for Carbenoxolone or Cholesterol
Comment Six diet-controlled nonobese diabetic patients with hemoglobin A(1c) less than 8%, and six matched controls participated in a double-blind, cross-over comparison of carbenoxolone (100 mg every 8 h, orally, for 7 d) and placebo. Carbenoxolone had the expected effects of raising blood pressure and lowering plasma potassium. Carbenoxolone reduced total cholesterol in healthy subjects, but had no effect on other serum lipids or on cholesterol in diabetic patients.
Formal Description
Interaction-ID: 30696

drug/chemical compound

Carbenoxolone

NOT affects_quantity of

drug/chemical compound

Cholesterol

in diabetic lean males
Drugbank entries Show/Hide entries for Carbenoxolone or Cholesterol