General Information:

Id: 3,318 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Homo sapiens
Pima Indians
article
Reference: Nair S et al.(2004) 11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle Diabetologia 47: 1088-1095 [PMID: 15156315]

Interaction Information:

Comment Among subjects with normal glucose tolerance, SNP1 (rs846910) and SNP5 rs12086634) were associated with insulin-mediated glucose uptake rates, and SNP1 was further associated with fasting, 30-min, and 2-h plasma insulin concentrations.
Formal Description
Interaction-ID: 30487

affects_activity of

process

glucose import

in Pima Indians, the risk allele is G
Comment Among subjects with normal glucose tolerance, SNP1 (rs846910) and SNP5 rs12086634) were associated with insulin-mediated glucose uptake rates, and SNP1 was further associated with fasting, 30-min, and 2-h plasma insulin concentrations.
Formal Description
Interaction-ID: 30488

affects_activity of

process

glucose import

in Pima Indians, the risk allele is G
Comment Adipocyte 11beta-HSD1 mRNA concentrations were correlated positively with adiposity and insulinaemia, and were additionally negatively correlated with insulin-mediated glucose uptake rates; nevertheless, the adipocyte 11beta-HSD1 expression did not correlate with genotypes of the donors.
Formal Description
Interaction-ID: 30492

gene/protein

HSD11B1

decreases_activity of

process

glucose import

in adipose tissue; in Pima Indians
Drugbank entries Show/Hide entries for HSD11B1
Comment The muscle 11beta-HSD1 mRNA concentrations did not correlate with any anthropometric or metabolic variables.
Formal Description
Interaction-ID: 30496

gene/protein

HSD11B1

NOT affects_activity of

process

glucose import

in skeletal muscle; in Pima Indians
Drugbank entries Show/Hide entries for HSD11B1