General Information:

Id: 3,311 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
Reference: Chen WT et al.(2011) Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-beta stability, oligomerization, and aggregation: amyloid-beta destabilization promotes annular protofibril formation J. Biol. Chem. 286: 9646-9656 [PMID: 21216965]

Interaction Information:

Comment Zn2+, Cu2+, Fe3+, and Al3+ adopt distinct folding and aggregation mechanisms to affect Abeta, where Abeta destabilization promotes annular protofibril formation.
Formal Description
Interaction-ID: 30445

drug/chemical compound


affects_folding of


Amyloid beta peptide