General Information:

Id: 3,311
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Chen WT et al.(2011) Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-beta stability, oligomerization, and aggregation: amyloid-beta destabilization promotes annular protofibril formation J. Biol. Chem. 286: 9646-9656 [PMID: 21216965]

Interaction Information:

Comment Zn2+, Cu2+, Fe3+, and Al3+ adopt distinct folding and aggregation mechanisms to affect Abeta, where Abeta destabilization promotes annular protofibril formation.
Formal Description
Interaction-ID: 30399

drug/chemical compound

Zn2+

affects_folding of

gene/protein

Amyloid beta peptide

Comment Zn2+, Cu2+, Fe3+, and Al3+ adopt distinct folding and aggregation mechanisms to affect Abeta, where Abeta destabilization promotes annular protofibril formation.
Formal Description
Interaction-ID: 30405

drug/chemical compound

Cu2+

affects_folding of

gene/protein

Amyloid beta peptide

Comment Abnormally high concentrations of Zn2+, Cu2+, and Fe3+ are present along with Abeta in the senile plaques in Alzheimer disease, where Al3+ is also detected.
Formal Description
Interaction-ID: 30443

phenotype

increased Zn2+ level

cooccurs with

Abnormally high concentrations of Zn2+ are present along with Abeta in the senile plaques in Alzheimer disease.
Comment Zn2+, Cu2+, Fe3+, and Al3+ adopt distinct folding and aggregation mechanisms to affect Abeta, where Abeta destabilization promotes annular protofibril formation.
Formal Description
Interaction-ID: 30444

drug/chemical compound

Al3+

affects_folding of

gene/protein

Amyloid beta peptide

Comment Zn2+, Cu2+, Fe3+, and Al3+ adopt distinct folding and aggregation mechanisms to affect Abeta, where Abeta destabilization promotes annular protofibril formation.
Formal Description
Interaction-ID: 30445

drug/chemical compound

Fe3+

affects_folding of

gene/protein

Amyloid beta peptide

Comment Abnormally high concentrations of Zn2+, Cu2+, and Fe3+ are present along with Abeta in the senile plaques in Alzheimer disease, where Al3+ is also detected.
Formal Description
Interaction-ID: 30446

phenotype

increased Cu2+ level

cooccurs with

Abnormally high concentrations of Cu2+ are present along with Abeta in the senile plaques in Alzheimer disease.
Comment Abnormally high concentrations of Zn2+, Cu2+, and Fe3+ are present along with Abeta in the senile plaques in Alzheimer disease, where Al3+ is also detected.
Formal Description
Interaction-ID: 30447

phenotype

increased Fe3+ level

cooccurs with

Abnormally high concentrations of Fe3+ are present along with Abeta in the senile plaques in Alzheimer disease.
Comment Abnormally high concentrations of Zn2+, Cu2+, and Fe3+ are present along with Abeta in the senile plaques in Alzheimer disease, where Al3+ is also detected.
Formal Description
Interaction-ID: 30448

phenotype

increased Al3+ level

cooccurs with

Abnormally high concentrations of Al3+ are present along with Abeta in the senile plaques in Alzheimer disease.