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Diseases	Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	323
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance Lipodystrophy, congenital generalized, type 1 - [OMIM]
Organism:	Mus musculus
Organism Model:	aP2-nSREBP-1c transgenic mouse; ob/ob mouse
Publication type:	article
Reference:	Shimomura I et al.(1999) Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401: 73-76 [PMID: 10485707]

Interaction Information:

Comment	Insulin resistance in lipodystrophic mice can be overcome by continuous systemic infusion of low doses of recombinant leptin, an effect that is not mimicked by chronic food restriction.
Formal Description Interaction-ID: 1271	gene/protein LEP decreases_activity of disease Insulin resistance in lipodystrophic mice

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