General Information:

Id: 323
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Lipodystrophy, congenital generalized, type 1 - [OMIM]
Mus musculus
aP2-nSREBP-1c transgenic mouse; ob/ob mouse
article
Reference: Shimomura I et al.(1999) Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401: 73-76 [PMID: 10485707]

Interaction Information:

Comment Insulin resistance in lipodystrophic mice can be overcome by continuous systemic infusion of low doses of recombinant leptin, an effect that is not mimicked by chronic food restriction.
Formal Description
Interaction-ID: 1271

gene/protein

LEP

decreases_activity of

disease

Insulin resistance

in lipodystrophic mice