CIDeRGeneral Information:
| Id: | 323 |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Lipodystrophy, congenital generalized, type 1 - [OMIM] |
| Mus musculus | |
| aP2-nSREBP-1c transgenic mouse; ob/ob mouse | |
| article | |
| Reference: | Shimomura I et al.(1999) Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy Nature 401: 73-76 [PMID: 10485707] |
Interaction Information:
| Comment | Insulin resistance in lipodystrophic mice can be overcome by continuous systemic infusion of low doses of recombinant leptin, an effect that is not mimicked by chronic food restriction. |
|
Formal Description Interaction-ID: 1271 |
|