General Information:

Id: 322 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000007 HEK-293 cells (transfected)
article
Reference: Yu G et al.(2000) Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing Nature 407: 48-54 [PMID: 10993067]

Interaction Information:

Comment Nicastrin binds carboxy-terminal derivatives of amyloid-beta precursor protein, and modulates the production of the amyloid-beta peptide (Ab) from these derivatives.
Formal Description
Interaction-ID: 14059

gene/protein

NCSTN

affects_quantity of

gene/protein

Amyloid beta peptide