General Information:

Id: 3,196 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
rat;Tg2576 mouse
Reference: Kotilinek LA et al.(2008) Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity Brain 131: 651-664 [PMID: 18292081]

Interaction Information:

Comment The non-selective NSAIDs (Non-steroid antiinflammatory drugs), ibuprofen and naproxen, and a selective COX-2 inhibitor, MF-tricyclic, each restored memory function in Tg2576 mice over-expressing APP, and also blocked Abeta-mediated inhibition of LTP.
Formal Description
Interaction-ID: 29525

drug/chemical compound


affects_activity of

mediated by Abeta
Drugbank entries Show/Hide entries for Ibuprofen