General Information:

Id: 3,196 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
rat;Tg2576 mouse
article
Reference: Kotilinek LA et al.(2008) Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity Brain 131: 651-664 [PMID: 18292081]

Interaction Information:

Comment The non-selective NSAIDs (Non-steroid antiinflammatory drugs), ibuprofen and naproxen, are COX-2 inhibitors.
Formal Description
Interaction-ID: 29373

drug/chemical compound

Ibuprofen

decreases_activity of

gene/protein

PTGS2

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Comment The non-selective NSAIDs (Non-steroid antiinflammatory drugs), ibuprofen and naproxen, and a selective COX-2 inhibitor, MF-tricyclic, each restored memory function in Tg2576 mice over-expressing APP, and also blocked Abeta-mediated inhibition of LTP.
Formal Description
Interaction-ID: 29522

drug/chemical compound

Ibuprofen

increases_activity of

process

memory

in Tg2576 mice over-expressing APP
Drugbank entries Show/Hide entries for Ibuprofen
Comment The non-selective NSAIDs (Non-steroid antiinflammatory drugs), ibuprofen and naproxen, and a selective COX-2 inhibitor, MF-tricyclic, each restored memory function in Tg2576 mice over-expressing APP, and also blocked Abeta-mediated inhibition of LTP.
Formal Description
Interaction-ID: 29525

drug/chemical compound

Ibuprofen

affects_activity of

mediated by Abeta
Drugbank entries Show/Hide entries for Ibuprofen
Comment Ibuprofen is a selective Abeta42-lowering agent (SALA).
Formal Description
Interaction-ID: 29593

drug/chemical compound

Ibuprofen

decreases_quantity of

Drugbank entries Show/Hide entries for Ibuprofen