General Information:

Id: 3,196
Diseases: Alzheimer disease - [OMIM]
Mammalia
rat;Tg2576 mouse
article
Reference: Kotilinek LA et al.(2008) Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity Brain 131: 651-664 [PMID: 18292081]

Interaction Information:

Comment The selective inhibition of COX-2, but not COX-1, acutely prevented the suppression of hippocampal long-term plasticity (LTP) by Abeta.
Formal Description
Interaction-ID: 29349

gene/protein

PTGS2

affects_activity of

gene/protein

Amyloid beta peptide

Drugbank entries Show/Hide entries for PTGS2
Comment The selective inhibition of COX-2, but not COX-1, acutely prevented the suppression of hippocampal long-term plasticity (LTP) by Abeta.
Formal Description
Interaction-ID: 29354

gene/protein

PTGS2

affects_activity of

in hippocampus; mediated by Abeta
Drugbank entries Show/Hide entries for PTGS2
Comment The selective inhibition of COX-2, but not COX-1, acutely prevented the suppression of hippocampal long-term plasticity (LTP) by Abeta.
Formal Description
Interaction-ID: 29355

gene/protein

Amyloid beta peptide

affects_activity of

in hippocampus; mediated by Abeta
Comment Selective COX-2 inhibitors are MF tricyclic and NS398. They partially prevented the inhibition of LTP by Abeta42.
Formal Description
Interaction-ID: 29368

drug/chemical compound

MF tricyclic

decreases_activity of

gene/protein

PTGS2

Drugbank entries Show/Hide entries for PTGS2
Comment Selective COX-2 inhibitors are MF tricyclic and NS398. They partially prevented the inhibition of LTP by Abeta42.
Formal Description
Interaction-ID: 29370

drug/chemical compound

COX-2 inhibitor NS398

decreases_activity of

gene/protein

PTGS2

Drugbank entries Show/Hide entries for PTGS2
Comment Selective COX-2 inhibitors are MF tricyclic and NS398. They partially prevented the inhibition of LTP by Abeta42.
Formal Description
Interaction-ID: 29371

drug/chemical compound

MF tricyclic

affects_activity of

mediated by Abeta42
Comment Selective COX-2 inhibitors are MF tricyclic and NS398. They partially prevented the inhibition of LTP by Abeta42.
Formal Description
Interaction-ID: 29372

drug/chemical compound

PTGS2 inhibitor NS398

affects_activity of

mediated by Abeta42
Comment The non-selective NSAIDs (Non-steroid antiinflammatory drugs), ibuprofen and naproxen, are COX-2 inhibitors.
Formal Description
Interaction-ID: 29373

drug/chemical compound

Ibuprofen

decreases_activity of

gene/protein

PTGS2

Drugbank entries Show/Hide entries for Ibuprofen or PTGS2
Comment The non-selective NSAIDs (Non-steroid antiinflammatory drugs), ibuprofen and naproxen, are COX-2 inhibitors.
Formal Description
Interaction-ID: 29374

drug/chemical compound

Naproxen

decreases_activity of

gene/protein

PTGS2

Drugbank entries Show/Hide entries for Naproxen or PTGS2
Comment The non-selective NSAIDs (Non-steroid antiinflammatory drugs), ibuprofen and naproxen, and a selective COX-2 inhibitor, MF-tricyclic, each restored memory function in Tg2576 mice over-expressing APP, and also blocked Abeta-mediated inhibition of LTP.
Formal Description
Interaction-ID: 29522

drug/chemical compound

Ibuprofen

increases_activity of

process

memory

in Tg2576 mice over-expressing APP
Drugbank entries Show/Hide entries for Ibuprofen
Comment The non-selective NSAIDs (Non-steroid antiinflammatory drugs), ibuprofen and naproxen, and a selective COX-2 inhibitor, MF-tricyclic, each restored memory function in Tg2576 mice over-expressing APP, and also blocked Abeta-mediated inhibition of LTP.
Formal Description
Interaction-ID: 29523

drug/chemical compound

Naproxen

increases_activity of

process

memory

in Tg2576 mice over-expressing APP
Drugbank entries Show/Hide entries for Naproxen
Comment The non-selective NSAIDs (Non-steroid antiinflammatory drugs), ibuprofen and naproxen, and a selective COX-2 inhibitor, MF-tricyclic, each restored memory function in Tg2576 mice over-expressing APP, and also blocked Abeta-mediated inhibition of LTP.
Formal Description
Interaction-ID: 29524

drug/chemical compound

PTGS2 inhibitor MF tricyclic

increases_activity of

process

memory

in Tg2576 mice over-expressing APP
Comment The non-selective NSAIDs (Non-steroid antiinflammatory drugs), ibuprofen and naproxen, and a selective COX-2 inhibitor, MF-tricyclic, each restored memory function in Tg2576 mice over-expressing APP, and also blocked Abeta-mediated inhibition of LTP.
Formal Description
Interaction-ID: 29525

drug/chemical compound

Ibuprofen

affects_activity of

mediated by Abeta
Drugbank entries Show/Hide entries for Ibuprofen
Comment The non-selective NSAIDs (Non-steroid antiinflammatory drugs), ibuprofen and naproxen, and a selective COX-2 inhibitor, MF-tricyclic, each restored memory function in Tg2576 mice over-expressing APP, and also blocked Abeta-mediated inhibition of LTP.
Formal Description
Interaction-ID: 29526

drug/chemical compound

Naproxen

affects_activity of

mediated by Abeta
Drugbank entries Show/Hide entries for Naproxen
Comment Ibuprofen is a selective Abeta42-lowering agent (SALA).
Formal Description
Interaction-ID: 29593

drug/chemical compound

Ibuprofen

decreases_quantity of

Drugbank entries Show/Hide entries for Ibuprofen
Comment Improved memory function was inversely related to prostaglandin E2 (PGE2) levels.
Formal Description
Interaction-ID: 29594

drug/chemical compound

Prostaglandin E2

affects_activity of

process

memory