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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	318 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Mus musculus
Tissue/Cell line:	BTO:0001487 adipose tissue
Publication type:	article
Reference:	Kim JB et al.(1998) Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1 J. Clin. Invest. 101: 1-9 [PMID: 9421459]

Interaction Information:

Comment	The promoters for both leptin and FAS are transactivated by ADD1/SREBP-1.
Formal Description Interaction-ID: 1261	gene/protein SREBF1 increases_expression of gene/protein LEP

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