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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
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Parkinson disease
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Postpartum depression
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	Field	Term

General Information:

Id:	3,185 (click here to show other Interactions for entry)
Diseases:	Alzheimer disease - [OMIM]
Organism:	Homo sapiens
Tissue/Cell line:	AD brain
Publication type:	article
Reference:	Qin W et al.(2009) PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia Arch. Neurol. 66: 352-361 [PMID: 19273754]

Interaction Information:

Comment	PGC-1alpha messenger RNA expression was significantly decreased in the AD brain.
Formal Description Interaction-ID: 29250	disease Alzheimer disease decreases_expression of gene/protein PPARGC1A in AD brain

Comment	The hippocampal PGC-1alpha protein content is inversely correlated with total Abetax-42 content. This association suggests that a decrease in PGC-1alpha expression in the AD brain might be associated with conditions promoting AD Abeta amyloidogenesis.
Formal Description Interaction-ID: 29255	gene/protein PPARGC1A affects_activity of phenotype amyloidosis PGC-1alpha content is inversely correlated with total Abetax-42 content

Comment	The hippocampal PGC-1alpha protein content is inversely correlated with total Abetax-42 content. This association suggests that a decrease in PGC-1alpha expression in the AD brain might be associated with conditions promoting AD Abeta amyloidogenesis.
Formal Description Interaction-ID: 62466	gene/protein PPARGC1A affects_quantity of gene/protein Amyloid beta peptide PGC-1alpha content is inversely correlated with total Abetax-42 content

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