General Information:

Id: 3,185 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
AD brain
article
Reference: Qin W et al.(2009) PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia Arch. Neurol. 66: 352-361 [PMID: 19273754]

Interaction Information:

Comment The hippocampal PGC-1alpha protein content is inversely correlated with total Abetax-42 content. This association suggests that a decrease in PGC-1alpha expression in the AD brain might be associated with conditions promoting AD Abeta amyloidogenesis.
Formal Description
Interaction-ID: 29255

gene/protein

PPARGC1A

affects_activity of

phenotype

amyloidosis

PGC-1alpha content is inversely correlated with total Abetax-42 content