General Information:

Id: 3,181 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
M17 cell line; brain from AD patients
article
Reference: Sheng B et al.(2012) Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimers disease J. Neurochem. 120: 419-429 [PMID: 22077634]

Interaction Information:

Comment Mitochondrial biogenesis is regulated by the peroxisome proliferator activator receptor gamma-coactivator 1a (PGC-1a)-nuclear respiratory factor (NRF)-mitochondrial transcription factor A pathway.
Formal Description
Interaction-ID: 29160

gene/protein

PPARGC1A

increases_activity of

process

mitochondrion biogenensis

Comment Expression levels of PGC-1a, NRF 1, NRF 2, and mitochondrial transcription factor A were significantly decreased in both AD hippocampal tissues and APPswe M17 cells.
Formal Description
Interaction-ID: 29169

decreases_expression of

gene/protein

PPARGC1A

in both AD hippocampal tissues and APPswe M17 cells
Comment Reduced expression of p-CREB and PGC-1a in APPswe M17 cells could be rescued by cAMP in a dose-dependent manner.
Formal Description
Interaction-ID: 29198

drug/chemical compound

cAMP

increases_expression of

gene/protein

PPARGC1A

in APPswe M17 cells
Drugbank entries Show/Hide entries for cAMP
Comment Reduced expression of p-CREB and PGC-1a in APPswe M17 cells could be rescued by cAMP in a dose-dependent manner.
Formal Description
Interaction-ID: 29205

tissue/cell line

APPswe M17 cell

decreases_expression of

gene/protein

PPARGC1A

Comment The fact that the treatment of PKA activator, cAMP, led to increased p-CREB and PGC-1a in a dose-dependent manner which could be completely abolished by specific PKA inhibitor H89 suggesting that the PKA/CREB pathway plays an important role in reduced expression of PGC-1a in APPswe M17 cells. Treatment of H89 could lead to further decreased levels of p-CREB and PGC-1a in APPswe M17 cells.
Formal Description
Interaction-ID: 29212

drug/chemical compound

PKA inhibitor H89

decreases_expression of

gene/protein

PPARGC1A

in APPswe M17 cells
Comment The PKA/CREB pathway plays an important role in reduced expression of PGC-1a in APPswe M17 cells.
Formal Description
Interaction-ID: 29239

process

PKA/CREB pathway

affects_expression of

gene/protein

PPARGC1A

in APPswe M17 cells