General Information:

Id: 3,181 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
M17 cell line; brain from AD patients
article
Reference: Sheng B et al.(2012) Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimers disease J. Neurochem. 120: 419-429 [PMID: 22077634]

Interaction Information:

Comment Expression levels of PGC-1a, NRF 1, NRF 2, and mitochondrial transcription factor A were significantly decreased in both AD hippocampal tissues and APPswe M17 cells.
Formal Description
Interaction-ID: 29169

decreases_expression of

gene/protein

PPARGC1A

in both AD hippocampal tissues and APPswe M17 cells