General Information:

Id: 3,181 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
M17 cell line; brain from AD patients
article/cited
Reference: Sheng B et al.(2012) Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimers disease J. Neurochem. 120: 419-429 [PMID: 22077634]

Interaction Information:

Comment Mitochondrial biogenesis is regulated by the peroxisome proliferator activator receptor gamma-coactivator 1a (PGC-1a)-nuclear respiratory factor (NRF)-mitochondrial transcription factor A pathway.
Formal Description
Interaction-ID: 29160

gene/protein

PPARGC1A

increases_activity of

process

mitochondrion biogenesis

Comment Expression levels of PGC-1a, NRF 1, NRF 2, and mitochondrial transcription factor A were significantly decreased in AD hippocampal tissues.
Formal Description
Interaction-ID: 29169

disease

Alzheimer disease

decreases_expression of

gene/protein

PPARGC1A

inAD hippocampal tissues
Comment The expression of NRF 1, NRF 2, and TFAM are regulated by peroxisome proliferation activator receptor gamma-coactivator 1alpha (PGC-1alpha) (Wu et al. 1999), the master regulator of mitochondrial biogenesis. (cited information)
Formal Description
Interaction-ID: 122730

gene/protein

PPARGC1A

affects_expression of

gene/protein

NRF1

Comment The expression of NRF 1, NRF 2, and TFAM are regulated by peroxisome proliferation activator receptor gamma-coactivator 1alpha (PGC-1alpha) (Wu et al. 1999), the master regulator of mitochondrial biogenesis. (cited information)
Formal Description
Interaction-ID: 122731

gene/protein

PPARGC1A

affects_expression of

gene/protein

NFE2L2

Comment The expression of NRF 1, NRF 2, and TFAM are regulated by peroxisome proliferation activator receptor gamma-coactivator 1alpha (PGC-1alpha) (Wu et al. 1999), the master regulator of mitochondrial biogenesis. (cited information)
Formal Description
Interaction-ID: 122732

gene/protein

PPARGC1A

affects_expression of

gene/protein

TFAM