General Information:

Id: 3,175
Diseases: Bipolar disorder
Circadian rhythm
Mus musculus
BTO:0001822 suprachiasmatic nucleus; BTO:0000763 lung; BTO:0000452 fibroblast
article
Reference: Li J et al.(2012) Lithium impacts on the amplitude and period of the molecular circadian clockwork PLoS ONE 7 [PMID: 22428012]

Interaction Information:

Comment Lithium lengthens period of the locomotor activity rhythm in the suprachiasmatic nucleus, lung tissues and fibroblast cells.
Formal Description
Interaction-ID: 29137

drug/chemical compound

Lithium

increases_quantity of

process

period of locomotor rhythm

Drugbank entries Show/Hide entries for Lithium
Comment Lithium increased expression of Per2 mRNA.
Formal Description
Interaction-ID: 29138

drug/chemical compound

Lithium

increases_expression of

gene/protein

PER2

Drugbank entries Show/Hide entries for Lithium
Comment Lithium increased the oscillation amplitude in both central and peripheral pacemakers.
Formal Description
Interaction-ID: 29139

drug/chemical compound

Lithium

increases_quantity of

process

oscillation amplitude of central pacemaker

Drugbank entries Show/Hide entries for Lithium
Comment Lithium increased the oscillation amplitude in both central and peripheral pacemakers.
Formal Description
Interaction-ID: 29140

drug/chemical compound

Lithium

increases_quantity of

process

oscillation amplitude of peripheral pacemaker

Drugbank entries Show/Hide entries for Lithium