General Information:

Id: 310 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1 wt or SOD1G93A or SOD1G85R transgenic mouse, transfected with human wt SOD1 or human SOD1G93A or human SOD1G85R
BTO:0000312 motoneuron
Reference: Raoul C et al.(2006) Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL Proc. Natl. Acad. Sci. U.S.A. 103: 6007-6012 [PMID: 16581901]

Interaction Information:

Comment In mutant SOD1G93A and SOD1G85R, but not in control motoneurons, the upregulation of FasL results in activation of Fas, leading through Daxx to phosphorylation of p38 and further NO synthesis by upregulation of nNOS. This Fas/NO feedback amplification loop is required for motoneuron death in vitro.
Formal Description
Interaction-ID: 13483



increases_quantity of

drug/chemical compound


in SOD1(G93A) or SOD1(G85R) mutant mice motoneurons
Drugbank entries Show/Hide entries for NOS1