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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	309 (click here to show other Interactions for entry)
Diseases:	Neurological
Organism:	Homo sapiens
Tissue/Cell line:	BTO:0000793 SH-SY5Y cell
Publication type:	article
Reference:	Smith WW et al.(2006) Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nat. Neurosci. 9: 1231-1233 [PMID: 16980962]

Interaction Information:

Comment	Alterations that reduce kinase activity of LRRK2-G2019S mutant reduce neuronal toxicity.
Formal Description Interaction-ID: 1223	gene/protein mutant LRRK2-p.G2019S increases_activity of process neuron death

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