General Information:

Id: 3,078 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
streptozotocin (STZ)-treated rat
Reference: Moreira PI et al.(2004) Effect of streptozotocin-induced diabetes on rat brain mitochondria. J. Neuroendocrinol. 16: 32-38 [PMID: 14962073]

Interaction Information:

Comment 4-week diabetic rats presented higher mitochondrial respiratory chain enzymatic activities, especially succinate-cytochrome C reductase activity, compared to 4-week control rats. In 9-week diabetic rats, only a significant decrease in cardiolipin content was observed; however, a significant increase in mitochondrial glutathione (GSH) content occurred.
Formal Description
Interaction-ID: 28301


Streptozocin-induced diabetes

increases_quantity of

drug/chemical compound


in mitochondria; in 9-week diabetic rats
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