General Information:

Id: 3,040 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Major depressive disorder - [OMIM]
Mus musculus
Reference: Lambillotte C et al.(1997) Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets. J. Clin. Invest. 99: 414-423 [PMID: 9022074]

Interaction Information:

Comment The inhibition of the insulin secretion by dexamethasone could not be ascribed to a lowering of insulin stores (higher in dexamethasone-treated islets), to an alteration of glucose metabolism (glucose oxidation and NAD(P)H changes were unaffected), or to a lesser rise of cytoplasmic Ca2+ in beta cells (only the frequency of the oscillations was modified).
Formal Description
Interaction-ID: 27969

drug/chemical compound


NOT affects_activity of

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for Dexamethasone