CIDeRGeneral Information:
| Id: | 3,040 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Major depressive disorder - [OMIM] |
| Mus musculus | |
| male | |
| article | |
| Reference: | Lambillotte C et al.(1997) Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets. J. Clin. Invest. 99: 414-423 [PMID: 9022074] |
Interaction Information:
| Comment | The inhibition of the insulin secretion by dexamethasone could not be ascribed to a lowering of insulin stores (higher in dexamethasone-treated islets), to an alteration of glucose metabolism (glucose oxidation and NAD(P)H changes were unaffected), or to a lesser rise of cytoplasmic Ca2+ in beta cells (only the frequency of the oscillations was modified). |
|
Formal Description Interaction-ID: 27969 |
drug/chemical compound NOT affects_activity of process |
| Drugbank entries | Show/Hide entries for Dexamethasone |