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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	3,030 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance Major depressive disorder - [OMIM]
Organism:	Mammalia
Publication type:	article
Reference:	Huising MO et al.(2010) CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner Proc. Natl. Acad. Sci. U.S.A. 107: 912-917 [PMID: 20080775]

Interaction Information:

Comment	Corticotropin-releasing factor (CRF), originally characterized as the principal neuroregulator of the hypothalamus-pituitary-adrenal axis. CRF receptor type 1 (CRFR1) is expressed on primary pancreatic beta cells and activation of pancreatic CRFR1 promotes insulin secretion, thus contributing to the restoration of normoglycemic equilibrium.
Formal Description Interaction-ID: 27835	gene/protein CRHR1 increases_activity of process insulin secretion involved in cellular response to glucose stimulus

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