General Information:

Id: 3,030 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Major depressive disorder - [OMIM]
Reference: Huising MO et al.(2010) CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner Proc. Natl. Acad. Sci. U.S.A. 107: 912-917 [PMID: 20080775]

Interaction Information:

Comment Corticotropin-releasing factor (CRF), originally characterized as the principal neuroregulator of the hypothalamus-pituitary-adrenal axis. CRF receptor type 1 (CRFR1) is expressed on primary pancreatic beta cells and activation of pancreatic CRFR1 promotes insulin secretion, thus contributing to the restoration of normoglycemic equilibrium.
Formal Description
Interaction-ID: 27835