General Information:

Id: 3,019 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Major depressive disorder - [OMIM]
Mammalia
review
Reference: Gragnoli C(2012) Depression and type 2 diabetes: Cortisol pathway implication and investigational needs J. Cell. Physiol. 227: 2318-2322 [PMID: 21898408]

Interaction Information:

Comment Elevated cortisol levels increase insulin resistance by regulating the insulin-responsive glucose transport system, specifically by impairing insulin ability to translocate intracellular glucose transporters type 4 (Glut4) to the cell surface. Glut4 is essential in mediating the insulin action in the adipose tissue.
Formal Description
Interaction-ID: 27770

phenotype

increased cortisol level

affects_activity of

process

glucose import