General Information:

Id: 2,989 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Hedskog L et al.(2012) Strategic role for mitochondria in Alzheimers disease and cancer Antioxid. Redox Signal. 16: 1476-1491 [PMID: 21902456]

Interaction Information:

Comment Active caspase-3 and -6 (CASP3, CASP6) , which both can cleave PS-1, have been found in the AD brain.
Formal Description
Interaction-ID: 72211

gene/protein

CASP3

decreases_quantity of

gene/protein

PSEN1

in AD brain; by cleaving PSEN1
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