General Information:

Id: 2,989 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Hedskog L et al.(2012) Strategic role for mitochondria in Alzheimers disease and cancer Antioxid. Redox Signal. 16: 1476-1491 [PMID: 21902456]

Interaction Information:

Comment Caspase cleavage of presenilin-1 (PS1) causes an elevation in intracellular Abeta42/Abeta40 ratio.
Formal Description
Interaction-ID: 27334

gene/protein

CASP

increases_processing of

gene/protein

PSEN1

Comment Caspase cleavage of presenilin-1 (PS1) causes an elevation in intracellular Abeta42/Abeta40 ratio.
Formal Description
Interaction-ID: 27350

protein modification

PSEN1-proc

affects_activity of

gene/protein

PSEN1

Comment PS1 has been shown to regulate P53 expression and this regulation is lost by AD-related PS1 mutations generating increased levels of p53 and thereby cell deat.
Formal Description
Interaction-ID: 27360

gene/protein

PSEN1

affects_activity of

of P53
Comment PS1 also regulates lysosomal proteolysis and autophagy which also has been shown to be compromised by AD-related PS1 mutation.
Formal Description
Interaction-ID: 27368

gene/protein

PSEN1

affects_activity of

(lysosomal proteolysis)
Comment PS1 also regulates lysosomal proteolysis and autophagy which also has been shown to be compromised by AD-related PS1 mutation.
Formal Description
Interaction-ID: 27369

gene/protein

PSEN1

affects_activity of

Comment Active caspase-3 and -6 (CASP3, CASP6) , which both can cleave PS-1, have been found in the AD brain.
Formal Description
Interaction-ID: 27385

gene/protein

CASP3

increases_processing of

gene/protein

PSEN1

in AD brain
Drugbank entries Show/Hide entries for CASP3
Comment Active caspase-3 and - 6 (CASP3, CASP6) , which both can cleave PS-1, have been found in the AD brain.
Formal Description
Interaction-ID: 27386

gene/protein

CASP6

increases_processing of

gene/protein

PSEN1

in AD brain
Comment Active caspase-3 and -6 (CASP3, CASP6) , which both can cleave PS-1, have been found in the AD brain.
Formal Description
Interaction-ID: 72211

gene/protein

CASP3

decreases_quantity of

gene/protein

PSEN1

in AD brain; by cleaving PSEN1
Drugbank entries Show/Hide entries for CASP3
Comment Active caspase-3 and - 6 (CASP3, CASP6) , which both can cleave PS-1, have been found in the AD brain.
Formal Description
Interaction-ID: 72212

gene/protein

CASP6

decreases_quantity of

gene/protein

PSEN1

in AD brain; by cleaving PSEN1