General Information:

Id: 2,989 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Hedskog L et al.(2012) Strategic role for mitochondria in Alzheimers disease and cancer Antioxid. Redox Signal. 16: 1476-1491 [PMID: 21902456]

Interaction Information:

Comment PS1 also regulates lysosomal proteolysis and autophagy which also has been shown to be compromised by AD-related PS1 mutation.
Formal Description
Interaction-ID: 27368

gene/protein

PSEN1

affects_activity of

(lysosomal proteolysis)