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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	297
Diseases:	Amyotrophic lateral sclerosis
Organism:	Homo sapiens
Tissue/Cell line:	BTO:0001009 PC-12 cell
Publication type:	article
Reference:	Sebastia J et al.(2009) Angiogenin protects motoneurons against hypoxic injury Cell Death Differ. 16: 1238-1247 [PMID: 19444281]

Interaction Information:

Comment	Wild-type ANG showed significantly reduced levels of hypoxia-induced apoptosis, whereas the K40I or R31K mutant forms did not reduce the levels of apoptosis in response to hypoxia.
Formal Description Interaction-ID: 1190	gene/protein ANG decreases_activity of process apoptotic process hypoxia induced
Drugbank entries	Show/Hide entries for ANG
Drugbank DB02212	Pyrophosphate 2- not specified ANG
Drugbank DB03088	Pyroglutamic Acid not specified ANG
Drugbank DB04272	Citric Acid not specified ANG
Drugbank DB02212	Pyrophosphate 2- not specified ANG
Drugbank DB03088	Pyroglutamic Acid not specified ANG
Drugbank DB04272	Citric Acid not specified ANG

Comment	Wild-type ANG showed significantly reduced levels of hypoxia-induced apoptosis, whereas the K40I or R31K mutant forms did not reduce the levels of apoptosis in response to hypoxia.
Formal Description Interaction-ID: 1194	gene/protein mutant ANG-p.K40I NOT decreases_activity of process apoptotic process hypoxia induced

Comment	Wild-type ANG showed significantly reduced levels of hypoxia-induced apoptosis, whereas the K40I or R31K mutant forms did not reduce the levels of apoptosis in response to hypoxia.
Formal Description Interaction-ID: 1195	gene/protein mutant ANG-p.R31K NOT decreases_activity of process apoptotic process hypoxia induced

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