General Information:

Id: 2,977 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
MODY, type VI - [OMIM]
Mus musculus
neuroD beta-CKO mouse: mouse in which neuroD is deleted in insulin-expressing cells
article
Reference: Gu C et al.(2010) Pancreatic beta cells require NeuroD to achieve and maintain functional maturity Cell Metab 11: 298-310 [PMID: 20374962]

Interaction Information:

Comment Pdx-1, Nkx6.1, and MafA, all of which are beta cell transcription factors that are involved in the activation of insulin transcription and the regulation of insulin secretion, are unaffected by the absence of NeuroD. These results indicate that the defective GSIS observed in neuroD beta-CKO mice is not a secondary consequence of altered regulation of these transcription factors.
Formal Description
Interaction-ID: 27121

gene/protein

PDX1

increases_activity of

process

insulin secretion involved in cellular response to glucose stimulus

in pancreas, in pancreatic islets