General Information:

Id: 2,973 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
MODY, type IV - [OMIM]
Reference: Gauthier BR et al.(2009) PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression Cell Metab. 10: 110-118 [PMID: 19656489]

Interaction Information:

Comment Mutations in the transcription factor Pdx1 cause maturity-onset diabetes of the young 4 (MODY4). Islet transduction with dominant-negative Pdx1 (RIPDN79PDX1) impairs mitochondrial metabolism and glucose-stimulated insulin secretion (GSIS).
Formal Description
Interaction-ID: 27089