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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	2,973 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance MODY, type IV - [OMIM]
Organism:	Mammalia
Publication type:	article
Reference:	Gauthier BR et al.(2009) PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression Cell Metab. 10: 110-118 [PMID: 19656489]

Interaction Information:

Comment	Mutations in the transcription factor Pdx1 cause maturity-onset diabetes of the young 4 (MODY4). Islet transduction with dominant-negative Pdx1 (RIPDN79PDX1) impairs mitochondrial metabolism and glucose-stimulated insulin secretion (GSIS).
Formal Description Interaction-ID: 27089	gene/protein PDX1 increases_activity of process insulin secretion involved in cellular response to glucose stimulus

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