General Information:

Id: 2,909
Diseases: Alzheimer disease - [OMIM]
Tauopathy
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Chen KL et al.(2010) Amyloid-beta peptide alteration of tau exon-10 splicing via the GSK3beta-SC35 pathway Neurobiol. Dis. 40: 378-385 [PMID: 20615469]

Interaction Information:

Comment In tauopathy, TAU accumulates as a consequence of altered pre-mRNA splicing of MAPT/TAU exon 10, resulting in 3R (without exon 10)/4R (with exon 10) imbalance.
Formal Description
Interaction-ID: 26675

affects_activity of

disease

Tauopathy

Comment In tauopathy, TAU accumulates as a consequence of altered pre-mRNA splicing of MAPT/TAU exon 10, resulting in 3R (without exon 10)/4R (with exon 10) imbalance.
Formal Description
Interaction-ID: 26684

affects_quantity of

mRNA/protein variant

MAPT-var (4R)

Comment In tauopathy, TAU accumulates as a consequence of altered pre-mRNA splicing of MAPT/TAU exon 10, resulting in 3R (without exon 10)/4R (with exon 10) imbalance.
Formal Description
Interaction-ID: 26685

affects_quantity of

mRNA/protein variant

MAPT-var (3R)

Comment In tauopathy, TAU accumulates as a consequence of altered pre-mRNA splicing of MAPT/TAU exon 10, resulting in 3R (without exon 10)/4R (with exon 10) imbalance.
Formal Description
Interaction-ID: 26686

affects_activity of

disease

Tauopathy

Comment In tauopathy, TAU accumulates as a consequence of altered pre-mRNA splicing of MAPT/TAU exon 10, resulting in 3R (without exon 10)/4R (with exon 10) imbalance.
Formal Description
Interaction-ID: 26711

mRNA/protein variant

MAPT-var

affects_activity of

disease

Tauopathy

via 4R/3R imbalance
Comment Lithium is a GSK-3beta inhibitor.
Formal Description
Interaction-ID: 26712

drug/chemical compound

Lithium

decreases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for Lithium or GSK3B
Comment SC35-tau exon 10 interaction was enhanced following Abeta treatment.
Formal Description
Interaction-ID: 26716

gene/protein

SRSF2

interacts (colocalizes) with

mRNA/protein variant

MAPT-var (4R)

after Amyloid beta peptide treatment
Comment Abeta activates GSK-3beta.
Formal Description
Interaction-ID: 26726

gene/protein

Amyloid beta peptide

increases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B
Comment Abeta activates GSK-3beta which in turn phosphorylates SC35.
Formal Description
Interaction-ID: 26747

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

SRSF2

Drugbank entries Show/Hide entries for GSK3B
Comment Abeta activates GSK-3beta which in turn phosphorylates SC35.
Formal Description
Interaction-ID: 26748

gene/protein

GSK3B

affects_activity of

gene/protein

SRSF2

Drugbank entries Show/Hide entries for GSK3B
Comment Abeta activates GSK-3beta which in turn phosphorylates SC35. This, alters tau exon 10 splicing, resulting in an increase in the tau 3R/4R ratio.
Formal Description
Interaction-ID: 26749

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

SRSF2

Drugbank entries Show/Hide entries for GSK3B
Comment Abeta activates GSK-3beta which in turn phosphorylates SC35. This, alters tau exon 10 splicing, resulting in an increase in the tau 3R/4R ratio.
Formal Description
Interaction-ID: 26750

protein modification

SRSF2-phos

affects_quantity of

mRNA/protein variant

MAPT-var (3R/4R)

Comment Abeta activates GSK-3beta which in turn phosphorylates SC35. This, alters tau exon 10 splicing, resulting in an increase in the tau 3R/4R ratio.
Formal Description
Interaction-ID: 26752

protein modification

SRSF2-phos

affects_activity of

Comment In tauopathy, TAU accumulates as a consequence of altered pre-mRNA splicing of MAPT/TAU exon 10, resulting in 3R/4R imbalance.
Formal Description
Interaction-ID: 27393

mRNA/protein variant

MAPT-var (3R/4R)

affects_activity of

disease

Tauopathy