General Information:

Id: 2,904
Diseases: Breast cancer - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Zakikhani M et al.(2006) Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res. 66 [PMID: 17062558]

Interaction Information:

Comment Metformin acts as a growth inhibitor rather than an insulin sensitizer for MCF-7 human breast cancer cells.
Formal Description
Interaction-ID: 26629

drug/chemical compound

Metformin

decreases_activity of

Drugbank entries Show/Hide entries for Metformin
Comment Metformin up-regulates AMP kinase activity in MCF-7 breast cancer cells. Western blot analysis indicated that metformin stimulates AMPK phosphorylation in a dose-dependent manner.
Formal Description
Interaction-ID: 26630

drug/chemical compound

Metformin

increases_activity of

complex/PPI

AMPK

Drugbank entries Show/Hide entries for Metformin
Comment AMPK activation is associated with decreased phosphorylation of mTOR and S6 kinase.
Formal Description
Interaction-ID: 26634

complex/PPI

AMPK

decreases_activity of

gene/protein

MTOR

Drugbank entries Show/Hide entries for MTOR
Comment AMPK activation is associated with decreased phosphorylation of mTOR and S6 kinase.
Formal Description
Interaction-ID: 26635

complex/PPI

AMPK

decreases_activity of

gene/protein

RPS6KB1

Comment Acetyl-CoA carboxylase (ACC) is also regulated by AMP kinase and an increase in P-ACC with metformin was observed.
Formal Description
Interaction-ID: 26637

complex/PPI

AMPK

increases_activity of

gene/protein

ACAC

Comment A general decline in protein synthesis was seen on exposure to growth inhibitory concentrations of metformin.
Formal Description
Interaction-ID: 26639

drug/chemical compound

Metformin

decreases_activity of

process

translation

Drugbank entries Show/Hide entries for Metformin