General Information:

Id: 289 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
BTO:0000312 motoneuron
article
Reference: Sebastia J et al.(2009) Angiogenin protects motoneurons against hypoxic injury. Cell Death Differ. 16: 1238-1247 [PMID: 19444281]

Interaction Information:

Comment ANG expression is induced under hypoxia in motoneurons.
Formal Description
Interaction-ID: 1151

increases_expression of

gene/protein

ANG

exposed to atmospheric hypoxia of 10, 3 and 1% O(2) for 24 h
Drugbank entries Show/Hide entries for ANG
Comment VEGF expression is induced under hypoxia in motoneurons.
Formal Description
Interaction-ID: 1155

increases_expression of

gene/protein

VEGFA

exposed to atmospheric hypoxia of 10, 3 and 1% O(2) for 24 h
Drugbank entries Show/Hide entries for VEGFA
Comment There was strong HIF-1-alpha stabilization in primary motoneurons under hypoxic conditions.
Formal Description
Interaction-ID: 1170

increases_expression of

gene/protein

HIF1A

already detectable after 4 h at 1% O(2)
Drugbank entries Show/Hide entries for HIF1A