General Information:

Id: 2,831 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Hundal RS et al.(2000) Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes 49: 2063-2069 [PMID: 11118008]

Interaction Information:

Comment The rate of gluconeogenesis was three times higher in the diabetic subjects than in the control subjects and metformin reduced that rate by 36%.
Formal Description
Interaction-ID: 26130

increases_activity of

process

gluconeogenesis

in liver
Comment The rate of gluconeogenesis was three times higher in the diabetic subjects than in the control subjects and metformin reduced that rate by 36%.
Formal Description
Interaction-ID: 26131

drug/chemical compound

Metformin

decreases_activity of

process

gluconeogenesis

in liver
Drugbank entries Show/Hide entries for Metformin
Comment Both gluconeogenesis and glycogenolysis contribute to hepatic glucose production.
Formal Description
Interaction-ID: 26132

process

gluconeogenesis

increases_activity of

process

hepatic glucose production

in liver